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. 2021 May 13;13:650350. doi: 10.3389/fnagi.2021.650350

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Copyright © 2021 Nishijima, Kimura, Mori, Wakabayashi, Kinoshita, Nakamura, Kon, Suzuki and Tomiyama.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time chart and experimental design of the study. We performed 6-OHDA surgery to develop hemi-parkinsonian rat models at 10 or 88 weeks of age. Dopaminergic denervation was confirmed by apomorphine test. The animals were then divided into five experimental groups. Rats received either L-dopa or saline daily and were sacrificed after the last treatment. 6-OHDA, 6-hydroxydopamine; L-dopa, levo-dihydroxyphenylalanine; OL-OD, old-lesioned old-L-dopa group; OL-OS, old-lesioned old-saline group; YL-OD, young-lesioned old-L-dopa group; YL-YD, young-lesioned young-L-dopa group; YL-YS, young-lesioned young-saline group, W, week.