FIGURE 4.

Exogenous WT BMDM decrease lung inflammation and infection in vivo. CF mice (n = 12) and WT controls (n = 10) were chronically infected with P. aeruginosa and followed for up to 10 days. Mice were infused with 10⁶ WT BMDM at day 1 post-infection. Animals were euthanized and evaluated for (A) white cell count, including a decrease in neutrophils (insert), (B) gross lung pathology and (C) P. aeruginosa infection burden. Treatment with bone marrow derived macrophages resulted in significantly (*) decreased recruitment of white blood cells improved gross lung pathology score and bacterial burden (p < 0.05).