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. 2021 May 13;12:573065. doi: 10.3389/fphar.2021.573065

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Copyright © 2021 van Heeckeren, Sutton, Fletcher, Hodges, Caplan and Bonfield.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hMSCs improve BMDM Inflammatory Response to Pathogens. CF BMDM (n = 3) preparations and WT BMDM (n = 2) treated with LPS demonstrated IL-6 and TNFα secretion. This was used as to explore the suppressive capacity of three different bone marrow donor hMSC supernatants. LPS stimulated CF and WT BMDM produce both IL-6 and TNFα. Treatment of the different BMDM preparations with the different hMSCs donor preparations resulted in cumulative decreased IL-6 (p ≤ 0.05) and TNFα (p ≤ 0.05) regardless of whether the BMDM were derived from CF (A,B) or WT mice (C,D). This is consistent with previously published data (Leyendecker et al., 2018).