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. 2021 May 13;12:573065. doi: 10.3389/fphar.2021.573065

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Copyright © 2021 van Heeckeren, Sutton, Fletcher, Hodges, Caplan and Bonfield.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hMSC Effect on PPARγ and TNFα expression. BMDM from CF patients and CF mice were evaluated for PPARγ (A). Sputum was obtained from CF patients (n = 3) and compared to healthy control (n = 3), demonstrating deficient PPARγ (p ≤ 0.05). BMDM from Cftr deficient mice also had deficient expression of PPARγ (p ≤ 0.05). (B) BMDM were stimulated with LPS and processed for PPARγ and TNFα gene expression demonstrating a decreased of PPARγ (p ≤ 0.05) and increased TNFα (p ≤ 0.05) relative to the unstiluated control of PPARγ and TNFα (2.1 ± 0.07 dCT and 1.7 ± 1.0 dCt respectively, n = 3) at baseline. The same culture conditions were done in the presence of hMSC condition medium. hMSC supernatants increased PPARγ and decreased TNFα (p ≤ 0.05) above the baseline controls.