Figure 5.

In vivo¹⁹F MRI study of inflamed mice. Ten days post-immunization, mice (N = 4) were subcutaneously injected with LPL-Sm:CaF₂ NCs (right leg, labeled as “R”) and PL-Sm:CaF₂ NCs (left, labeled as “L”). Then, 2 h post-injection mice were anesthetized and scanned with MRI. (a) ¹H MRI, (b) ¹⁹F MRI, and (c) ¹H/¹⁹F MRI overlay of a representative mouse. (d) SNR of ¹⁹F MRI at the LNs ROIs (N = 4, Student’s test, * represents a p value <0.05). The in-plane resolutions of the ¹H MR and ¹⁹F MR images are 0.35 × 0.2 mm² and 1.4 × 0.78 mm², respectively; the slice thickness is 1 mm in ¹H MRI and 0.78 mm in ¹⁹F MRI.