Table IV.

Association analysis of serum sRAGE levels and other biochemical parameters with 374T/A genotypes in DNR and DR groups.

DNR GROUP
Mean ± SD	TT (n=120)	TA (n=26)	AA (n=4)	p-value	Multinomial Regression p-value
Serum sRAGE (pg/ml)	553.0 ± 207.6	714.3 ± 159.1	592.1 ± 45.9	0.001*	0.001*
FPG (mg/dl)	162.7 ± 50.6	175.5 ± 56.5	164.3 ± 56.7	0.48
Total cholesterol (mg/dl)	201.8 ± 41.4	212.1 ± 50.4	192.4 ± 40.7	0.54
HDL-C (mg/dl)	43.5 ± 8.5	44.5 ± 7.4	49.5 ± 5.7	0.21
LDL-C (mg/dl)	127.6 ± 41.1	136.3 ± 44.7	103.5 ± 42.5	0.19
Triglyceride (mg/dl)	183.8 ± 65.7	170.7 ± 50.0	170.8 ± 67.5	0.55
Urea (mg/dl)	30.1 ± 9.1	33.2 ± 10.0	32.5 ± 9.2	0.26
Creatinine (mg/dl)	1.10 ± 0.38	1.17 ± 0.31	0.96 ± 0.36	0.33
DR GROUP
	TT (n=115)	TA (n=29)	AA (n=6)	p-value
Serum sRAGE (pg/ml)	569.1 ± 229.6	696.4 ± 255.4	729.7 ± 224.1	0.026*	0.01*
FPG (mg/dl)	192.1 ± 56.2	189.7 ± 55.5	172.8 ± 32.9	0.70
Total cholesterol (mg/dl)	218.8 ± 40.8	223.8 ± 46.2	244.0 ± 40.2	0.34
HDL-C (mg/dl)	44.4 ± 8.0	47.6 ± 7.9	44.0 ± 7.0	0.15
LDL-C (mg/dl)	141.7 ± 36.7	145.1 ± 45.2	168.8 ± 32.2	0.21
Triglyceride (mg/dl)	176.1 ± 44.1	170.9 ± 40.7	176.6 ± 42.2	0.84
Urea (mg/dl)	33.2 ± 9.9	32.8 ± 8.8	34.1 ± 6.4	0.94
Creatinine (mg/dl)	1.17 ± 0.38	1.24 ± 0.38	1.28 ± 0.42	0.58

“DNR, diabetic with no retinopathy; DR, diabetic retinopathy; sRAGE, soluble RAGE; p value < 0.05 significant;

^*TT vs TA.”