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. 2021 May 13;12:681150. doi: 10.3389/fmicb.2021.681150

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Copyright © 2021 Sanders, Ullah, Gehring, Burkhart, Vickerman, Fernando, Gardner, Ben-Hur and Santangelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disruption of 3-dimensional chromatin structure results in genome instability in T. kodakarensis. (A) A circos plot comparing TS620 to TS600. The outermost black circle represents genomic position. The outer coverage plot (blue) represents Fragments Per Kilobase of transcript per Million mapped reads (FPKM) for TS620. The inner coverage plot (purple) represents FPKM for TS600. Notably, nearly zero reads mapped to TKVR2 in TS620 (highlighted in yellow). Red lines represent fragments enriched in TS600 while green lines represent fragments enriched in TS620. (B) A loci diagram of the annotated T. kodakarensis viral region 2 (TKVR2: TK0381-TK0421) that highlights the observed region of excision (∼TK0389 – ∼TK0412) superimposed over a genome alignment plot derived from PacBio long read sequencing of TS620.