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. 2021 May 13;12:639782. doi: 10.3389/fphys.2021.639782

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Copyright © 2021 McKetton, Sam, Poublanc, Crawley, Sobczyk, Venkatraghavan, Duffin, Fisher and Mikulis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Seed-to-voxel functional connectivity results. The first panel shows greater connectivity in the isocapnic condition (red) compared to the poikilocapnic condition; seed regions (red 10 mm ROIs) are depicted by the small axial brain images (top left), and red cluster regions shown in left sagittal, superior axial, and right sagittal views. (A) Left putamen seed, precuneus cortex cluster; (B) Right putamen seed, left occipital pole and right lateral occipital cortex clusters. Panels 2–4 show greater connectivity in the poikilocapnic condition (blue) compared to the isocapnic condition; seed regions (blue 10 mm ROIs), and blue cluster regions in the left sagittal and superior axial view. (A) primary visual network (PVN) seed, hippocampal formation cluster; (B) ICC seed, Hippocampus (Hi) cluster; (C) left SCC seed, Hi cluster; (D) right SCC seed, Hi/lingual gyrus cluster; (E) posterior cerebellar seed; supramarginal gyrus (SG) cluster; (F) Cerebellum region 9 seed; superior parietal lobule (SPL) cluster. Only significant family-wise error (FWE) corrected p < 0.05 are reported.