Figure 9.

HOXB9 promoted the proliferation of brain metastatic tumor cells through promoting the G1/S transition of the cell cycle. (A) Downregulation of HOXB9 in LLC-BrM decreased the proliferation, *p < 0.05. (B) Flow cytometry analysis determined the decreasing proportion of cells in the S phase of the cell cycle as the downregulation of HOXB9 in LLC-BrM. (C) Intersection analysis established the common cell-cycle-associated genes potentially transcribed by HOXB9 (Hoxb9) shared by both human and mouse. (D) Enrichment analysis of BP category in GO database for the 30 common genes potentially transcribed by HOXB9, terms enriched with p- and q-values were <0.05. (E) Enrichment analysis with signaling pathways in KEGG database for the 30 common cell cycle-associated genes. The p- and q-values of these enriched terms were both <0.05.