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. 2021 May 13;12:682415. doi: 10.3389/fimmu.2021.682415

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Copyright © 2021 Zhao, Ou and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic value of NRGs in LGG and GBM. Univariate and multivariate Cox regression of NRG1-4 in LGG (A) and GBM (B). Nomogram to predict the 1, 2 and 3-year overall survival of patients with LGG (C) and GBM (D). The dashed diagonal line represents the ideal nomogram, and the blue, red and orange lines represent the 1, 2 and 3-year observed nomograms, respectively. Risk model and prognostic analysis of NRG3 in LGG (E), and NRG1 in GBM (F), respectively. The prognostic risk model shows the Risk type (top left), patient status (middle left) and mRNA expression heatmap (bottom left), and Kaplan–Meier curves of OS (top right) and time-dependent ROC (bottom right) for NRG3 in LGG (E) and NRG1 in GBM (F).