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. 2021 May 13;12:682415. doi: 10.3389/fimmu.2021.682415

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Copyright © 2021 Zhao, Ou and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between NRGs expression and neoantigens/immune checkpoint in LGG and GBM. Correlation analysis of NRG1-4 expression and neoantigen counts in LGG and GBM (A). The horizontal axis represents the expression distribution of NRG1-4, and the ordinate is the distribution of neoantigen counts. The density curve on the right represents the distribution trend of neoantigen counts; the upper density curve represents the distribution trend of NRG1-4. Correlations between immune checkpoint-related genes and the expression of NRG1-4 in LGG and GBM (B). Spearman’s correlation analysis was used to describe the correlation. *P < 0.05; **P <0.01; ***P < 0.001.