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. 2021 May 13;12:670122. doi: 10.3389/fimmu.2021.670122

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Copyright © 2021 Weng, Li, Li, Liu, Chen and Shiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thioester-Containing Protein 1 (TEP1) Transgenic Mosquito Enhances Dengue Virus (DENV) Infection. (A) Aedes aegypti control and loss-of-function transgenic (AaCPA>2miR-TEP1) mosquitoes were fed an infectious DENV blood meal. The whole bodies of infected mosquitoes were collected 0, 2, 4, 6, 8, 10, and 12 days after the infectious blood meal and viral titers were determined and quantified with a plaque assay. (B) Ae. aegypti mosquitoes with silenced TEP1 or mosquitoes from the loss-of-function transgenic line were fed an infectious DENV blood meal. Midguts from infected mosquitoes were collected seven days after the infectious blood meal and the viral titers were determined by plaque assay. Letters indicate the statistical significance according to Tukey’s multiple comparison test. There is no significant difference between them (p > 0.05). Control: Aedes aegypti UGAL/Rockefeller strain without any transgenic materials or dsRNA treatment.