Table 1. Top 10 Enriched Pathways Ranked by the Combined Scorea.
| (A) WikiPathways database (Human) – OA/T2DM– group | ||
|---|---|---|
| pathway ID | pathway description | combined score |
| WP3601 | composition of lipid particles* | 451.49 |
| WP1533 | vitamin B12 metabolism* | 217.78 |
| WP4522 | metabolic pathway of LDL, HDL and TG* | 214.40 |
| WP12 | osteoclast signaling | 214.40 |
| WP408 | oxidative stress | 200.60 |
| WP3967 | miR-509-3p alteration of YAP1/ECM axis | 197.94 |
| WP176 | folate metabolism* | 147.28 |
| WP2911 | miRNA targets in ECM and membrane receptors | 140.40 |
| WP100 | glutathione metabolism | 132.24 |
| WP111 | electron transport chain (OXPHOS system in mitochondria) | 130.27 |
| (B) KEGG database (Human) – OA/T2DM– group | |
|---|---|
| name | combined score |
| protein digestion and absorption | 158.74 |
| riboflavin metabolism* | 117.32 |
| ECM-receptor interaction | 107.60 |
| glutathione metabolism | 95.87 |
| oxidative phosphorylation | 88.73 |
| arachidonic acid metabolism* | 80.90 |
| taurine and hypotaurine metabolism | 77.74 |
| Huntington disease | 77.55 |
| focal adhesion | 73.86 |
| fatty acid biosynthesis* | 62.42 |
| (C) WikiPathways database (Human) – OA/T2DM+ group | ||
|---|---|---|
| pathway ID | pathway description | combined score |
| WP1589 | folate-alcohol and cancer pathway hypotheses | 223.62 |
| WP4225 | pyrimidine metabolism and related diseases | 223.62 |
| WP4146 | macrophage markers | 223.62 |
| WP206 | fatty acid omega oxidation* | 117.34 |
| WP497 | urea cycle and metabolism of amino groups | 80.93 |
| WP2533 | glycerophospholipid biosynthetic pathway* | 75.94 |
| WP3580 | methionine de novo and salvage pathway | 71.45 |
| WP1539 | angiogenesis | 63.73 |
| WP2878 | PPAR alpha pathway* | 57.32 |
| WP167 | eicosanoid synthesis* | 54.52 |
| (D) KEGG database (Human) – OA/T2DM+ group | |
|---|---|
| name | combined score |
| fat digestion and absorption* | 347.52 |
| pantothenate and CoA biosynthesis* | 86.52 |
| renin-angiotensin system | 67.40 |
| vitamin digestion and absorption* | 63.73 |
| alpha-linolenic acid metabolism* | 60.38 |
| linoleic acid metabolism* | 49.56 |
| beta-alanine metabolism | 45.32 |
| pancreatic secretion | 41.93 |
| drug metabolism | 36.35 |
| glycine, serine, and threonine metabolism | 32.04 |
a
(A) Top 10 enriched pathways in the OA/T2DM– group from WikiPathways database. (B) Top 10 enriched pathways in the OA/T2DM– group from KEGG database. (C) Top 10 enriched pathways in the OA/T2DM+ group from WikiPathways database. (D) Top 10 enriched pathways in the OA/T2DM+ group from KEGG database. The (*) displays the pathways related to lipid regulation.