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. 2021 Apr 14;20(5):2560–2569. doi: 10.1021/acs.jproteome.0c01000

Figure 1.

Figure 1

MS Annika search engine. The MS Annika Detector identifies potential ion doublets and passes the spectra to the search node if doublets are found. Spectra with identified ion doublets are searched using the MS Annika Search node. The final combination of CSM matches to cross-links as well as multilevel FDR control fall into the scope of the MS Annika Validator node. The optional xiView Exporter node can be used to export cross-links at different confidence levels, which can then be uploaded to xiView for evaluation.