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. 2021 May 13;11:658489. doi: 10.3389/fonc.2021.658489

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Copyright © 2021 Dervan, Bhattacharyya, McAuliffe, Khan and Glynn

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HML-2 Proviral Structure. HML-2 proviral integrations have either a type I or type II genome delineated by the respective presence (type I) or absence (type II) of a 292 bp deletion at the pol/env boundary. The full length transcript codes for the Gag precursor and Gag-Pro/Gag-Pro-Pol fusion proteins that are processed by the viral protease and cellular proteasome respectively. Singly sliced HML-2 mRNA encodes the Env protein, while a secondary slicing event of env mRNA gives rise to the Rec (type II) or Np9 (type I) accessory proteins. Splice donor (SD) and splice acceptor (SA) sites are indicated (type II loci combine SD2 and SA2 for rec splicing while type I loci contain the alternative SD3 site for np9 transcript generation). Created with BioRender.com.