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. 2021 May 13;12:661316. doi: 10.3389/fendo.2021.661316

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Copyright © 2021 Du, Yu, Li, Yu, Yang, Jiang and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic Testing and Validation Results. The WES result indicated that the MDM4 amplified in this thymoma cells, which is the unique driver gene in 99 mutated genes among 20,000 exons (A); Immunohistochemical staining showed positivity for MDM4 (B) and negativity for p53 (C); The drug sensitivity test showed that the growth rate of thymoma cells was 41.22% in Nutlin-3a group, compared with 78.66% in the control group, which meant that the thymoma cells were highly sensitive to Nutlin-3a (D).