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. 2021 May 13;12:681424. doi: 10.3389/fphar.2021.681424

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Copyright © 2021 Zhang, Zheng, Wang, Lin, Wang, Liu, Yan, Chen, Yang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of VHH-0031 on JAK2-STAT3 signaling pathway in STZ-induced rats kidney. The mRNA expression of IL-6 (A), JAK2 (B), STAT3 (C),TNF-α (D) and TGF-β1 (E) in kidney determined by qRT-PCR (F) The expression of JAK2 and STAT3 staining measured by immunohistochemistry in kidney,Bar = 100 μm ( ×400). Quantification of JAK2 (G) and STAT3 (H) protein measured by immunohistochemical staining. Data represents the mean ± SD for six rats per group. Control: SD rats without STZ treatment, Model: SD rats with STZ treatment, Benazepril 10 mg kg⁻¹: SD rats with STZ treatment in presence of benazepril (10 mg kg⁻¹), VHH-0031 0.1 and 0.5 mg kg⁻¹: SD rats with STZ treatment in presence of the recombinant anti-IL-6R fusion proteins (0.1 and 0.5 mg kg⁻¹). **p < 0.01, ***p < 0.001 vs control group, ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs model group.