Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 13;12:681424. doi: 10.3389/fphar.2021.681424

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Zhang, Zheng, Wang, Lin, Wang, Liu, Yan, Chen, Yang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effect of VHH-0031 suppresses JAK2/STAT3 pathway in high-glucose and IL-6siRNA stimulated mesangial cells. Cells were treated with random sequence IL-6siRNA (Si-NC), or random sequence IL-6siRNA and VHH-0031(Si-NC + VHH-0031 5pM), or IL-6siRNA, or IL-6siRNA and VHH-0031 (IL-6siRNA + VHH-0031 5 pM) in the presence of high glucose (HG). The mRNA expression level of IL-6 (A), JAK2 (B), STAT3 (C), TGF-β1 (D) and Cyclin D1 (E) in HBZY-1 cells were detected by qRT-PCR. *p < 0.05, ***p < 0.001 vs HG group, ^### p < 0.001 vs IL-6siRNA group.