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. 2021 May 13;12:681424. doi: 10.3389/fphar.2021.681424

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Copyright © 2021 Zhang, Zheng, Wang, Lin, Wang, Liu, Yan, Chen, Yang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Flowchart describes renoprotective effect of the recombinant anti-IL-6R fusion proteins (VHH-0031) by inhibiting IL6R/JAK2/STAT3 signaling pathway in diabetic nephropathy. The red of the flowchart is express that the high glucose induces kidney injury and upregulates IL6R/JAK2/STAT3 signaling pathway. After treated by anti-IL-6R fusion proteins (VHH-0031) downregulates IL6R/JAK2/STAT3 signaling pathway. The above improvement results are reflected in green.