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. 2021 May 13;12:652782. doi: 10.3389/fimmu.2021.652782

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Copyright © 2021 Wang, Zhao, Wang, Sun, Zou, Li, Liu, Lin, Zhou, Ning, Tian and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRX3 silencing accelerates pyroptosis in APAP-induced hepatotoxicity in mice. (A) PRX3 protein levels in mice liver were determined, n=3. (B) Liver PRX3 mRNA expression, n=6. (C) Schematic representation of AAV9-TBG-shRNA injection through tail vein in mice. (D) Liver sections were analyzed by immunohistochemical staining for PRX3 (50μm). (E) Liver sections were stained with H&E (50μm). The damaged areas are indicated with arrows. (F) Serum levels of ALT and AST were assessed, n=8. (G) Serum levels of LDH were assessed, n=8. (H, I) Serum levels of IL-1β and IL-18, n=8. (J) PRX3, caspase-1 p20 and GSDMD-Nin mice liver were determined, n=3. (K) H₂O₂ level, n = 8.**P<0.01.