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Illustration of the mechanism by which PRX3 alleviates APAP-induced pyroptosis. Excessive APAP promotes NLRP3-mediated pyroptosis in mice. The crosstalk between KCs and hepatocytes amplifies the pyroptotic signal. PRX3 overexpression alleviates the above process by disrupting NLRP3 inflammasome activation. Moreover, PRX3 regulates NLRP3 inflammasome activation by targeting mitochondrial ROS.
