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. 2021 May 13;12:650983. doi: 10.3389/fphar.2021.650983

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Copyright © 2021 Zhou, He, Zhu, Lin, Chen, Shao, Wan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GHI attenuated OGD-induced injury by regulating the PI3K/Akt pathway. (A) Representative immunoblots of Akt, p-Akt, Bax, Bcl-2, cleaved caspase-3, and caspase-3 proteins. (B) The ratio of p-Akt/Akt. (C) The ratio of Bcl-2/Bax. (D) The levels of caspase-3. (E) The levels of cleaved caspase-3. Data are shown as the mean ± SD (n = 3). ^# p < 0.05, ^## p < 0.01 compared with the Control group; ^* p < 0.05, ^** p < 0.01 compared with the OGD group, ^Δ p < 0.05, ^ΔΔ p < 0.01 compared with the GHI 100 μL/ml group.