TABLE 2.
Identified novel variants with genome-wide significant associations.
SNP | Nearest gene | Trait | Chromosome position | Minor allele | MAF | Discovery (n = 2,869) |
Replication (n = 37,321) |
Combination (n = 40,169) |
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β ± SE | P value | β ± SE | P value | β ± SE | P value | ||||||
rs1307273 | RP11-513I15.6 | Height–women | 6:34240886 | G | 0.205 | 0.82 ± 0.17 | 9.27 × 10–7 | 0.33 ± 0.04 | 5.19 × 10–14 | 0.37 ± 0.04 | 3.37 × 10–17 |
rs9469757 | RP11-513I15.6 | Height–women | 6:34232864 | C | 0.170 | 0.87 ± 0.18 | 1.16 × 10–6 | 0.37 ± 0.05 | 1.41 × 10–14 | 0.40 ± 0.05 | 3.10 × 10–17 |
rs1759637 | RP11-513I15.6 | Height–women | 6:34237130 | C | 0.193 | 0.82 ± 0.17 | 1.62 × 10–6 | 0.32 ± 0.05 | 4.49 × 10–12 | 0.35 ± 0.04 | 8.54 × 10–15 |
rs7133285 | RP11-977G19.10 | Height–women | 12:56699429 | A | 0.232 | −0.75 ± 0.16 | 2.25 × 10–6 | −0.67 ± 0.04 | 2.27 × 10–54 | −0.67 ± 0.04 | 4.19 × 10–58 |
rs9469761 | RP11-513I15.6 | Height–women | 6:34236429 | A | 0.169 | 0.85 ± 0.18 | 2.53 × 10–6 | 0.37 ± 0.05 | 1.38 × 10–14 | 0.40 ± 0.05 | 3.25 × 10–17 |
rs1776890 | RP11-513I15.6 | Height–women | 6:34237747 | G | 0.194 | 0.79 ± 0.17 | 3.62 × 10–6 | 0.32 ± 0.05 | 9.86 × 10–13 | 0.35 ± 0.04 | 1.51 × 10–15 |
rs13207853 | RP11-513I15.6 | Height–women | 6:34238946 | C | 0.181 | 0.81 ± 0.18 | 4.64 × 10–6 | 0.33 ± 0.05 | 1.57 × 10–12 | 0.37 ± 0.05 | 1.59 × 10–15 |
rs2797961 | RP11-513I15.6 | Height–women | 6:34237797 | G | 0.205 | 0.77 ± 0.17 | 4.67 × 10–6 | 0.32 ± 0.04 | 6.31 × 10–13 | 0.35 ± 0.04 | 9.07 × 10–16 |
rs200808496 | RP11-513I15.6 | Height–women | 6:34237376 | T | 0.203 | 0.75 ± 0.17 | 7.40 × 10–6 | 0.31 ± 0.04 | 9.98 × 10–12 | 0.33 ± 0.04 | 5.34 × 10–14 |
Age and residential area were included as covariants in all genetic models. Variants stated in the manuscript are indicated in bold. MAF, minor allele frequency; β, regression coefficient; SE, standard error; N, the number of participants included in each stage.