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. 2021 May 13;9:647763. doi: 10.3389/fcell.2021.647763

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Copyright © 2021 Huang, Chen, Feng, Chen, Yan, Yang, Xiao, Gao, Zhang and Ke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of CD31 directly by both ELF5 and SP1. Potential binding of ELF5 and SP1 to the promoter of CD31 and induction of the expression were examined by luciferase report assay (A). In HCF cells treated with control (IgG), NC/Exo, mMimics-1/Exo or Mimics-2/Exo, the association of miR-1246 and miR-1290 with the potential binding of ELF5 and SP1 to the DNA of CD31, respectively, was examined by CHIP (B) and EMSA (C). In HCFs that received non-transfection or transfection with OE-NC, OE-ELF, or OE-SP1 (si-NC, siELF5-1, siELF5-2, siSP1-1, or siSP1-2), the expression of CD31 was examined by qRT-PCR (D). N = 3. **P < 0.01 as compared with the NC group. Exo, exosomes; Mimics-1, miR-1246 mimics; Mimics-2, miR-1290 mimics.