TABLE 3.
Indicators | HR | LVESd (mm) | LVEDd (mm) | Vs (μ L) | Vd (μ L) | SV (μ L) | LVEF (%) | FS (%) | CO (mL/min) | LVPWT (mm) | LVAWT (mm) |
Sham | 35411.53 | 3.70.18 | 6.140.32 | 101.064.85 | 246.028.42 | 146.165.45 | 74.741.48 | 35.481.2 | 50.792 | 2.230.09 | 2.070.11 |
Model | 281.339.61** | 5.380.22** | 6.820.46 | 98.616.58 | 211.695.96** | 115.913.42** | 51.172.07** | 26.852.19** | 34.012.17** | 2.170.08 | 1.920.1 |
NC-Exo | 303.6712.7 | 4.890.21 | 6.620.38 | 96.472.94 | 213.38.42 | 120.474.99 | 53.442.93 | 28.762 | 37.281.86 | 2.340.18 | 2.10.13 |
Mimics-1/Exo | 323.673.21## | 4.540.24## | 6.710.3 | 100.172.5 | 229.772.1# | 131.543.03## | 60.452.07## | 32.580.95## | 43.743.29## | 2.270.07 | 1.960.09 |
Mimics-2/Exo | 327.6711.02## | 4.120.28## | 6.620.27 | 97.943.47 | 237.574.53## | 136.862.35 | 65.172.54## | 34.310.79## | 45.392.55## | 2.150.07 | 2.070.08 |
**P < 0.01 vs. sham group, #P < 0.05, ##P < 0.01 vs. model group. Exo, exosomes; Mimics-1, miR-1246 mimics; Mimics-2, miR-1290 mimics; Inhibitor-1, miR-1246 inhibitors; Inhibitor-2, miR-1290 inhibitors; HR, heart rate; LVESd, left ventricular end systolic diameter; LVEDd, left ventricular end-diastolic diameter; Vs, systolic left ventricular volume; Vd, diastolic left ventricular volume; SV, stroke volume; LVEF, left ventricular ejection fraction; FS, fractional shortening; CO, cardiac output; LVPWT, left ventricular posterior wall thickness; LVAWT, left ventricular diastolic anterior wall thickness.