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Proposed model of EXO-mediated regulation of NSCs. Embryonic NSCs secrete exosomes enriched with miR-9. After internalizing by neighboring NSCs, exosomes release miR-9 into the recipient cells, leading to the repression of differentiation repressor gene, Hes1. The inhibition of Hes1 then facilitates the differentiation of NSCs and the maturation of both neuronal and glial cells.
