Table 1.

Baseline characteristics of the study populations.

	Hypothyroidism cohort	Control cohort	P-value
Total	501,882	1,505,646
Male	87,233 (17.4%)	261,699 (17.4%)	0.99
Female	414,649 (82.6%)	1,243,947 (82.6%)
Age
mean ± SD	50.6 ± 15.0	50.6 ± 15.0
<65 years	404,230 (80.5%)	1,212,690 (80.5%)	0.99
≥65 years	97,652 (19.5%)	292,956 (19.5%)
Days of prescription
<2 years	191,185 (38%)
≤2 to <4 years	111,937 (22%)
≤4 to <6 years	78,332 (16%)
≤6 years	120,428 (24%)
Comorbidities
Hypertension	119,420 (23.8%)	299,126 (19.9%)	<0.001
Diabetes	62,441 (12.4%)	123,070 (8.2%)	<0.001
Myocardial infarction	3,303 (0.7%)	5,818 (0.4%)	<0.001
Stroke	18,186 (3.6%)	42,165 (2.8%)	<0.001
Heart failure	8,901 (1.8%)	12,737 (0.8%)	<0.001
Renal failure	8,370 (1.7%)	5,998 (0.4%)	<0.001
Malignancy	20,997 (4.2%)	33,485 (2.2%)	<0.001

SD, standard deviation.