Table 2.

Incidence rates and hazard ratios for mortality in the hypothyroidism cohort and the control cohort.

	Hypothyroidism cohort		Control cohort		Hazard ratio for mortality
Subgroup	Number of deaths	Mortality rate [CI] (per 1,000 person-years)	Number of deaths	Mortality rate [CI] (per 1,000 person-years)	Crude HR* [CI]	Adjusted HR** [CI]
All	25,954	8.66 [8.33–9.00]	59,105	6.53 [6.37–6.70]	1.33 [1.31–1.35]	1.14 [1.12–1.16]
Male	11,470	24.44 [23.04–25.90]	23,211	16.03 [15.38–16.69]	1.53 [1.49–1.56]	1.28 [1.25–1.31]
Female	14,484	5.73 [5.44–6.04]	35,894	4.72 [4.57–4.88]	1.21 [1.19–1.24]	1.06 [1.04–1.09]
Age groups
<65 years	8,649	3.49 [3.26–3.73]	16,275	2.18 [2.07–2.29]	1.60 [1.56–1.64]	1.25 [1.22–1.29]
≥65 years	17,305	33.69 [32.12–35.32]	42,830	27.25 [26.44–28.07]	1.24 [1.22–1.26]	1.08 [1.06–1.10]
Comorbidities
Low CVD risk group	8,111	3.64 [3.40–3.90]	25,157	3.52 [3.39–3.66]	1.03 [1.01–1.06]	1.10 [1.08–1.13]
High CVD*** risk group	17,843	23.19 [22.13–24.30]	33,948	17.81 [17.22–18.42]	1.30 [1.28–1.33]	1.31 [1.29–1.34]

CI, confidence interval; CVD, cardiovascular disease.

*Reference group is the control cohort.

**Adjusted for age, sex, and comorbidities in subgroup analysis. Sex subgroup is adjusted for age and comorbidities. Age subgroup is adjusted for sex and comorbidities. CVD risk subgroup is adjusted for age and sex.

***High CVD risk group is defined as the presence of hypertension, diabetes mellitus, or prevalent CVD (MI, stroke, and heart failure).