TABLE 1.

Anti-fibrotic or anti-inflammatory long non-coding RNAs (lncRNAs) in renal diseases.

lncRNA	Model	Mechanism/target	Pathological output(s)	Year	References
GAS5	STZ-induced DN and rat	Recruits EZH2 to the promoter region of MMP9	Anti-fibrotic; anti-inflammatory	2020	Zhang et al., 2020a
CRNDE	Sepsis-induced AKI, rat, and TECs	Regulation of miR-181a-5p/PPARα pathway	Anti-inflammatory	2020	Wang et al., 2020a
CCAT1	LPS-induced AKI mice and TECs	Overexpression of CCAT1 sequesters miR-155 and leads to upregulation of SIRT1 and TECs damage	Anti-inflammatory	2020	Lu et al., 2020
TUG1	SLE patient serum and SLE mouse	/	Anti-fibrotic; anti-inflammatory	2020	Cao et al., 2020a, b
	LPS-induced podocyte injury	Targets miR-197/MAPK1	Anti-inflammatory	2019	Zhao et al., 2019
Rian/RIAN	UUO mouse, AKI mouse, and pericytes	Possible interactions with 14q32 miRNA cluster	Anti-fibrotic	2019	Bijkerk et al., 2019
Malat1/MALAT1	AKI; mice; and TECs	Regulates HIF-1α expression through NF-κB signaling	Anti-inflammatory	2018	Tian et al., 2018
ZEB1-AS1	DN mouse and DN patient	Binds to H3K4 methyltransferase myeloid and MLL1 to promote ZEB1 expression Provides a binding site for p53	Anti-fibrotic	2018	Wang et al., 2018a
1700020I14Rik	DN mouse and MCs	Interacts with miR-34a-5p, Sirt1/HIF-1α	Anti-fibrotic	2018	Li et al., 2018
CYP4B1-PS1-001	DN mouse and MCs	Regulates Nucleolin to inhibit proliferation and fibrosis of MCs	Anti-fibrotic	2018 2016	Wang et al., 2016a, 2018c
3110045C21Rik	UUO mouse and TECs	Contains binding sites for Pol II and H3K4m3	Anti-fibrotic	2016	Arvaniti et al., 2016
ENSMUST00000147869	DN mouse and MCs	Possibly targets on Cyp4a12a gene	Anti-fibrotic	2016	Wang et al., 2016b