Table 4.
The significant HGNC gene families of the 927 feature genes, where the family is covered by at least five genes and with the Binomial test <0.05.
| HGNC family | Type | P-value | Potential impact |
|---|---|---|---|
| Immunoglobulin heavy locus at 14q32.33 | AMP | 3.18E-08 | Increased IGH expression, prognostic correlations |
| Olfactory receptors, family 52 | AMP | 6.83E-06 | Increased OR expression, prognostic correlations |
| Tripartite motif containing | AMP | 3.71E-04 | Transcription, cell growth, apoptosis |
| Olfactory receptors, family 51 | AMP | 7.10E-04 | Increased OR expression, prognostic correlations |
| HOXL subclass homeoboxes | AMP | 1.83E-03 | Oncogenesis, tumor suppression |
| Keratin associated proteins | AMP | 4.11E-03 | N/A |
| Glycoside hydrolases | AMP | 9.84E-03 | Invasion, metastasis |
| Glycosyltransferases | AMP | 3.26E-02 | Invasion, metastasis |
| Intermediate filaments | AMP | 3.44E-02 | Invasion, metastasis |
| Zinc fingers C2H2-type | AMP | 3.50E-02 | Transcription, multiple roles |
| ANTP class homeoboxes | DEL | 4.40E-05 | Oncogenesis, tumor suppression |