Table 2.
Risk factors for all ECC cases, its subtypes pCCA and dCCA and respective controls
| Risk factors | All ECC vs Controls | pCCA vs Controls | dCCA vs Controls | |||
|---|---|---|---|---|---|---|
| Odds Ratio (95% CI) | p-value | Odds Ratio (95% CI) | p-value | Odds Ratio (95% CI) | p-value | |
| Statin use | 0.22 (0.16–0.29) | <0.0001 | 0.3 (0.21–0.41) | <0.0001 | 0.06 (0.03–0.14) | <0.0001 |
| BMI | 0.97 (0.94–0.99) | 0.004 | 0.95 (0.92–0.98) | <0.001 | 1.01 (0.97–1.05) | 0.77 |
| DM | 0.73 (0.56–0.94) | 0.015 | 0.63 (0.46–0.87) | 0.005 | 0.94 (0.61–1.44) | 0.77 |
| IBD | 8.2 (4.17–16.15) | <0.0001 | 5.19 (2.44–11.02) | <0.001 | 6.16 (0.80–47.13) | 0.080 |
| Cirrhosis | 2.91 (2.02–4.19) | <0.0001 | 3.28 (2.18–4.94) | <0.001 | 1.88 (0.78–4.55) | 0.16 |
| HCV | 7.33 (2.94–18.31) | <0.0001 | 15.84 (4.06–61.87) | <0.001 | 1.51 (0.33–6.85) | 0.59 |
| Other liver disease | 4.01 (2.33–6.92) | <0.0001 | 4.06 (2.24–7.36) | <0.001 | 4.01 (2.33–6.92) | <0.001 |
| Smoking, n (%) | 1.00 (0.79–1.27) | 0.99 | 0.9 (0.67–1.22) | 0.49 | 1.25 (0.83–1.9) | 0.29 |
| Alcohol use, n (%) | 0.36 (0.28–0.47) | <0.0001 | 0.34 (0.25–0.48) | <0.0001 | 0.39 (0.25–0.6) | <0.0001 |