Table 5.
Survival analysis for all pCCA and dCCA cases (includes the unmatched cases)
| pCCA | dCCA | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate | Multivariate | Univariate | Multivariate | ||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.04 (1.02–1.05) | <0.001 | 1.01 (1–1.02) | <0.03 | 1.03 (1.01–1.05) | 0.003 | 1.03 (1–1.05) | 0.01 |
| Sex, male | 0.94 (0.68–1.29) | 0.69 | - | - | 0.61 (0.39–0.95) | 0.027 | 0.73 (0.45–1.17) | 0.19 |
| BMI | 1.0 (0.98–1.03) | 0.68 | - | - | 1.0 (0.95–1.04) | 0.94 | - | - |
| Statin use | 1.03 (0.71–1.49) | 0.87 | - | - | 0.49 (0.28–0.86) | 0.01 | 0.53 (0.29–0.97) | 0.04 |
| DM | 0.95 (0.68–1.34) | 0.78 | - | - | 0.92 (0.59–1.42) | 0.92 | - | - |
| IBD | 0.50 (0.31–0.82) | 0.006 | 0.62 (0.3–1.29) | 0.19 | 0.58 (0.23–1.44) | 0.24 | - | - |
| Cirrhosis | 0.41 (0.28–0.60) | <0.001 | 0.56 (0.36–0.89) | 0.01 | 1.26 (0.58–2.73) | 0.56 | - | - |
| Cholangitis after diagnosis | 1.07 (0.78–1.48) | 0.68 | - | - | 1.76 (1.04–2.96) | 0.035 | 1.61 (0.93–2.79) | 0.09 |
| PSC | 0.48 (0.34–0.67) | <0.001 | 0.84 (0.54–1.31) | 0.44 | 0.80 (0.48–1.31) | 0.37 | - | - |
| HCV | 0.38 (0.19–0.79) | 0.009 | 0.34 (0.15–0.81) | 0.01 | 2.03 (0.50–8.32) | 0.32 | - | - |
| Other liver disease | 0.47 (0.28–0.78) | 0.003 | 1.17 (0.63–2.18) | 0.61 | 2.41 (0.87–6.65) | 0.091 | 2.53 (0.9–7.06) | 0.08 |
| Smoking, n (%) | 1.28 (0.82–2.01) | 0.27 | - | - | 0.86 (0.41–1.82) | 0.69 | - | - |
| Alcohol use, n (%) | 1.1 (0.69–1.75) | 0.69 | - | - | 0.83 (0.39–1.81) | 0.65 | - | - |
| Stage of cancer | ||||||||
| Early | Reference | - | Reference | - | Reference | - | Reference | - |
| Late | 1.73 (1.26–2.37) | <0.001 | 1.39 (1–1.93) | 0.048 | 1.83(0.97–3.46) | 0.063 | 2.66 (1.28–5.52) | 0.009 |