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. 2021 May 13;11:656564. doi: 10.3389/fonc.2021.656564

Figure 1.

Figure 1

Identification of cancer cells in both primary and metastatic PDAC. (A) scRNA-seq data of ten primary (P0–P10) and metastatic (MET0–MET6) PDAC tumors were integrated. (B) Primary and metastatic PDAC samples were visualized by UMAP grouped by disease status. (C) The cells in the integrated data were divided into thirteen clusters (Clusters 0–12). (D) Transcripts of major cell type marker genes were visualized by UMAPs. (E) Six distinct cell types were defined based on the expression of cell type marker in (D). (F) Cell type of primary and metastatic PDAC by divided UMAPs. (G) Heatmap of top 100 genes of each cell type confirmed the distinct signatures of each defined cell type. CAF, cancer associated fibroblasts; cancer, cancer cell, dendritic, dendritic cells.