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. 2021 May 13;11:656564. doi: 10.3389/fonc.2021.656564

Figure 2.

Figure 2

Differentially expressed gene analysis of cancer cells from primary and metastatic PDAC. Cancer cells were extracted and clustered. (A) The distributions of each tumor sample were visualized. (B) The distribution of primary and metastatic PDAC cancer cells in extracted cancer cell data. (C) Cancer cell were clustered, and four clusters (Clusters 0–3) were identified. Comparative analysis was performed to calculate the DE genes between primary and metastatic PDAC cells. (D) Top 500 DE genes of both primary and metastatic PDAC cancer cells were visualized by heatmap. (E, F) Expression of representative top five genes of primary (E) and metastatic (F) PDAC cancer cells was visualized by UMAPs to compare their expression in primary and metastatic PDAC cancer cells. Notably, lincRNAs, LINC01133 and MEG3, showed specific expression in primary and metastatic PDAC cancer cells, respectively. (G) Violin plot visualization of expression levels of LINC01133 and MEG3 expression in primary and metastatic PDAC cancer cells. Dash purple lines indicated the Mean levels of gene expression.