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. 2021 May 13;11:656564. doi: 10.3389/fonc.2021.656564

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Copyright © 2021 Pan, Diao, Zhong, Wang, Wen and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC01133 and MEG3 marked primary and metastatic PDAC cancer cell clusters, respectively. (A) Relative expression and colocalization of LINC01133 and MEG3 in integrated cancer cells, primary and metastatic cancer cells by blended UMAPs. (B) Comparison of LINC01133 and MEG3 expression in each cluster between primary and metastatic cancer cells by split violin plots. Notably, MEG3⁺ cancer cells were mostly distributed in Cluster 1 and derived from metastatic PDAC cancer, while LINC01133 ⁺ cancer cells were mostly distributed in Clusters 2 and 3 and derived from primary PDAC cancer.