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. 2021 May 13;11:656564. doi: 10.3389/fonc.2021.656564

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Copyright © 2021 Pan, Diao, Zhong, Wang, Wen and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased EMT signatures in MEG3 ⁺ cancer cells. (A) Relative expression of EMT markers, including epithelial markers and mesenchymal markers, in each cluster were visualized by dot plot. (B) Decreased epithelial cell marker signatures and increased mesenchymal marker signatures in Cluster 1 were confirmed by violin plot visualization of representative EMT marker expression: CDH1, SDC1, MUC1, EPCAM, SNAI2, VIM, FN1 and S100A4. (C, D) Ingenuity Canonical Pathways (C) and Upstream Regulators (D) of Cluster 1 determined by IPA on significant DE genes. The arrow and arrowhead indicated signaling pathways and upstream regulators were cancer or cancer metastasis related. Asterisk indicated the EMT signaling pathway.