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The structure of IL-12 family. IL-12 family is composed of A chains (p19, p28, or p35) and B chains (p40 or Ebi3). P40 can be paired with p35 or p19 to form IL-12 or IL-23. Respectively, while Ebi3 can pair with p28 or p35 to form IL-27 or IL-35. IL-12 receptor is composed of IL-12R β2 and IL-12R β1. IL-23 receptor is composed of IL-12R β1 and IL-23R. IL-27 receptor is composed of WSX-1and gp-130. IL-35 receptor is composed of IL-12R β2 and gp-130.
