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. 2021 May 13;12:655114. doi: 10.3389/fphar.2021.655114

FIGURE 2.

FIGURE 2

A schematic model for the immune pathway of IL-35 in RA. Th1, Th2, Th17, and Treg are all differentiated from the Th Cells, which can differentiate into different cell subsets under the influence of different cytokines and transcription factors. As shown in the figure, IL-35 stimulates the differentiation of Th cells into Treg and iTR35. IL-10 and TGF-β are secreted by Treg, and IL-35 inhibits the differentiation of Th cells into other helper T cells, especially Th17. IL-35 also acts on DCs and macrophages to inhibit inflammation.