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. 2021 May 13;12:655114. doi: 10.3389/fphar.2021.655114

TABLE 1.

IL-12 family in RA.

Cytokines Producing cells Function References
IL-12 monocytes, macrophages,DCs,B cells Th1 differentiation; Th2 inhibition; IFN-γ↑ Wu et al. 2016
IL-23 monocytes, macrophages,DCs,B cells, endothelial cells Th17 differentiationIL-17↑ ; Proliferation of CD4+ memory T cells Nakano et al. 2015b
IL-27 macrophages,DCs,B cells Inhibition of immune system responses; limit the inflammatory Behzadi et al. 2016
IL-35 Tregs, breg, endothelial cells; monocytes Treg and breg differentiation; iTR35 differentiation; Th17 inhibition; teff inhibition; IL-35 and IL-10 ↑; M1macrophages↓; M2macrophages↑ Choi et al. 2015