TABLE 1.

IL-12 family in RA.

Cytokines	Producing cells	Function	References
IL-12	monocytes, macrophages,DCs,B cells	Th1 differentiation; Th2 inhibition; IFN-γ↑	Wu et al. 2016
IL-23	monocytes, macrophages,DCs,B cells, endothelial cells	Th17 differentiationIL-17↑ ; Proliferation of CD4+ memory T cells	Nakano et al. 2015b
IL-27	macrophages,DCs,B cells	Inhibition of immune system responses; limit the inflammatory	Behzadi et al. 2016
IL-35	Tregs, breg, endothelial cells; monocytes	Treg and breg differentiation; iTR35 differentiation; Th17 inhibition; teff inhibition; IL-35 and IL-10 ↑; M1macrophages↓; M2macrophages↑	Choi et al. 2015