TABLE 2.

The targets of IL-35 in RA.

Modulators	IL-35	Target	Model	References
	IL-35	IFN-γ	RA serum	Niedbala et al. 2007
Breg	IL-35	IL-10	PBMCs	Wang et al. 2014
iTR35	IL-35	IL-35	Mice	Collison et al. 2010
	IL-35	TNF-α	FLS	Wu et al. 2016c
Endothelial cells	IL-35	Ang2	Huvec	Jiang et al. 2016a
	IL-35	RANKL	FLS	Li et al. 2016a
	IL-35	OPG	CIA mice	Li et al. 2016d
	IL-35	P-STAT1	FLS	Wu et al. 2018
	IL-35	VEGF	FLS	Wu et al. 2018
Macrophages	IL-35	CCR-7	PBMCs	Peng et al. 2019
CD39+CD4+T cells	IL-35	Foxp3	Arthritis mice	Filkova et al. 2015
Th-17	IL-35	IL-17	Mice spleen cells	Kam et al. 2018b