Table 3.
Comparison of the intra-retinal layers between NHON (n = 110) and HON patients at baseline (n = 46).
| Intra-retinal layer volume | NHON versus HON patients | ||||
|---|---|---|---|---|---|
| NHON patients (mean ± SD) | HON patients (mean ± SD) | Ba | SEb | p-Valuec | |
| TMV (mm3) | 3.10 ± 0.16 | 2.95 ± 0.19 | −0.135 | 0.030 | <0.001 |
| mRNFL (mm3) | 0.22 ± 0.02 | 0.18 ± 0.02 | −0.029 | 0.004 | <0.001 |
| GCIPL (mm3) | 0.79 ± 0.09 | 0.65 ± 0.12 | −0.121 | 0.018 | <0.001 |
| INL (mm3) | 0.36 ± 0.03 | 0.36 ± 0.03 | 0.005 | 0.006 | 0.386 |
| OPL (mm3) | 0.31 ± 0.04 | 0.30 ± 0.02 | −0.016 | 0.006 | 0.013 |
| ONL (mm3) | 0.67 ± 0.07 | 0.68 ± 0.07 | 0.020 | 0.013 | 0.129 |
a
Regression coefficient (B) derived from linear regression.
b
Standard error derived from linear regression.
c
p-Value derived from linear regression adjusted for age, sex, EDSS and disease duration.
B, regression coefficient; EDSS, Expanded Disability Status Scale; GCIPL, ganglion cell and inner plexiform layer; HON, history of optic neuritis; INL, inner nuclear layer; mRNFL, macular retinal nerve fiber layer; NHON, no history of optic neuritis; ONL, outer nuclear layer; OPL, outer plexiform layer; SD, standard deviation; SE, standard error; TMV, total macular volume.
Bold values indicate statistical significance at the p < 0.05 level.