Table 4.
Correlation of sNfL and intra-retinal layer volumes of HON patients (n = 46) with OCT measurement 2.4 years after sNfL draw.
| Intra-retinal layer volume | Log sNfL versus intra-retinal layer volumes in HON patients | |||
|---|---|---|---|---|
| HON patients (mean ± SD) | Ba | SEb | p-Valuec | |
| TMV (mm3) | 2.95 ± 0.19 | 0.387 | 0.378 | 0.312 |
| mRNFL (mm3) | 0.18 ± 0.02 | 4.939 | 2.795 | 0.085 |
| GCIPL (mm3) | 0.65 ± 0.12 | 1.018 | 0.530 | 0.062 |
| INL (mm3) | 0.36 ± 0.03 | –1.448 | 2.052 | 0.485 |
| OPL (mm3) | 0.30 ± 0.02 | −6.734 | 2.514 | 0.011 |
| ONL (mm3) | 0.68 ± 0.07 | 0.215 | 1.005 | 0.831 |
| sNfL (pg/ml) | 16.8 ± 27.4 | |||
Regression coefficient (B) derived from linear regression.
Standard error derived from linear regression.
p-Value derived from linear regression adjusted for age, sex, EDSS, disease duration and relapses within 180 days of sNfL draw.
B, regression coefficient; EDSS, Expanded Disability Status Scale; GCIPL, ganglion cell and inner plexiform layer; HON, history of optic neuritis; INL, inner nuclear layer; mRNFL, macular retinal nerve fiber layer; OCT, optical coherence tomography; ONL, outer nuclear layer; OPL, outer plexiform layer; SD, standard deviation; SE, standard error; sNfL, serum neurofilament light chain; TMV, total macular volume.
Bold values indicate statistical significance at the p < 0.05 level.