Table 5.
Correlation of sNfL and intra-retinal layer volumes of NHON patients (n = 110) with OCT measurement 1.6 years after sNfL draw.
| Intra-retinal layer volume | Log sNfL versus OCT in NHON patients | |||
|---|---|---|---|---|
| NHON patients (mean ± SD) | Ba | SEb | p-Valuec | |
| TMV (mm3) | 3.10 ± 0.16 | 0.401 | 0.304 | 0.189 |
| mRNFL (mm3) | 0.22 ± 0.02 | 1.016 | 2.203 | 0.646 |
| GCIPL (mm3) | 0.79 ± 0.09 | 0.151 | 0.551 | 0.784 |
| INL (mm3) | 0.36 ± 0.03 | 1.352 | 1.585 | 0.396 |
| OPL (mm3) | 0.31 ± 0.04 | −0.488 | 1.294 | 0.707 |
| ONL (mm3) | 0.67 ± 0.07 | 1.222 | 0.623 | 0.053 |
| sNfL ( pg/ml) | 19.0 ± 33.1 | |||
Regression coefficient (B) derived from linear regression.
Standard error derived from linear regression.
p-Value derived from linear regression adjusted for age, sex, EDSS, disease duration and relapses within 180 days of sNfL draw.
B, regression coefficient; EDSS, Expanded Disability Status Scale; GCIPL, ganglion cell and inner plexiform layer; INL, inner nuclear layer; mRNFL, macular retinal nerve fiber layer; NHON, no history of optic neuritis; OCT, optical coherence tomography; ONL, outer nuclear layer; OPL, outer plexiform layer; SD, standard deviation; SE, standard error; sNfL, serum neurofilament light chain; TMV, total macular volume.