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. 2021 May 25;218(8):e20201708. doi: 10.1084/jem.20201708

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© 2021 Chen et al.

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Figure 5. — SERCA2 deficiency impairs B cell development in vivo. (A) Western blot analysis of SERCA2 and actin in cells isolated from Atp2a2^flox/flox and Atp2a2^flox/flox:mb1-cre mice. Bone marrow (BM), whole spleen (SP - unsort), and purified splenic B cells (SP - B cell) were analyzed (n = 1). (B–D) Mean ± SD of the percentages of proB (B), preB (C), and mature splenic B (D) cells assayed by flow-cytometric analysis of BM (B and C) and spleen (D) from mb1-cre (n = 7), Atp2a2^flox/flox (n = 8), and Atp2a2^flox/flox:mb1-cre (n = 12) mice. *, P < 0.05; **, P < 0.01; ***, P < 0.001. (E) Percentage of CD19⁺ B cells in the peripheral blood of Darier disease (DD) individuals (median with 95% CI; mean, 11.4%; n = 16). The normal laboratory range (9–24%) for the percentage of B cells in peripheral blood is indicated by the dotted lines. expo., exposure.