Table 2:
Characteristics of clinical outcomes in all the patients and by treatment groups*.
| Outcomes | N | All | Without Leukapheresis | Leukapheresis | P value |
|---|---|---|---|---|---|
| Response | 766 | 0.036 | |||
| CR | 386 (50.4%) | 339 (51.5%) | 47 (43.5%) | ||
| CRi | 105 (13.7%) | 84 (12.8%) | 21 (19.4%) | ||
| No Response | 246 (32.1%) | 214 (32.5%) | 32 (29.6%) | ||
| PR | 29 (3.8%) | 21 (3.2%) | 8 (7.4%) | ||
| Death in the first 30 days | 755 | 126 (16.7%) | 112 (17.3%) | 14 (13.2%) | 0.329 |
| ICU Admission | 484 | 96 (19.8%) | 44 (10.7%) | 52 (72.2%) | <0.001 |
| Hemodialysis Required | 621 | 68 (11%) | 56 (10.6%) | 12 (12.8%) | 0.59 |
| Mechanical Ventilation Required | 226 | 32 (14.2%) | 13 (7.7%) | 19 (33.3%) | <0.001 |
| Relapse after initial response | 453 | 193 (42.6%) | 149 (38.8%) | 44 (63.8%) | <0.001 |
| Hematopoietic Stem Cell Transplant | 505 | 157 (31.1%) | 124 (29.5%) | 33 (39.3%) | 0.093 |
| Median Duration of CR in months (IQR) | 247 | 202(114–363) | 208(133–368) | 171(78–280) | 0.192 |
| Median Overall Survival in months (95% CI) | 12.6(11.5,14.9) | 12.0(10.4, 13.9) | 18.8(13.3,32.5) | 0.07 | |
*
For categorical variables, the comparisons between treatment groups were based on Fisher’s exact test. For continuous variables, the comparisons were based on Wilcoxon rank sum test. Log rank test was used to compare the overall survival between two groups.