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. 2021 May 25;218(7):e20210223. doi: 10.1084/jem.20210223

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© 2021 Ho et al.

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Figure 10. — Minimal pro-aging effects are observed in HSCs from progeroid mice. (A–F) Analysis of 3-mo-old control (Cn) and progeroid Lm mice with (A) experimental setup; (B) lineage distribution in the peripheral blood of primary animals; and (C) frequency, CD150 levels, and γH2AX immunofluorescence staining (scale bar, 10 µm), (D) regenerative capacity following transplantation into lethally irradiated primary recipients (250 HSCs/recipient), (E) lineage distribution in primary recipients, and (F) regenerative capacity following transplantation into lethally irradiated secondary recipients (500 HSCs/recipient) for the indicated HSC populations. (G–L) Analysis of 11-mo-old control (Cn) and progeroid Bubr1^H/H (Bu) mice with (G) experimental setup; (H) lineage distribution in the peripheral blood of primary animals; (I) frequency and CD150 levels, (J) regenerative capacity following transplantation into lethally irradiated recipients (250 HSCs/recipient), and (K) lineage distribution of the indicated HSC populations; and (L) frequency of the indicated endosteal BM niche populations. MFI, mean fluorescence intensity. Data are means ± SD; *, P ≤ 0.05.