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. 2021 May 25;218(7):e20210223. doi: 10.1084/jem.20210223

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© 2021 Ho et al.

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Figure 4. — Injection of young plasma does not functionally rejuvenate old HSCs. (A) Experimental setup for the saline (Sa) or young plasma (Pl) injection experiments in young and old mice. (B) Quantification of MCM2- and DCX-positive cells in the DG of old saline- or plasma-injected mice. (C) HSC frequency in indicated mice. Uninjected Y controls are included for comparison. (D) CD150 mean fluorescence intensity (MFI) levels for the indicated HSC populations. (E) Regenerative capacity for the indicated HSC populations following transplantation into lethally irradiated recipients (250 HSCs/recipient). Results show overall engraftment in the peripheral blood over time. (F) Lineage distribution for the indicated HSC populations at 4 mo after transplantation in blood (right) and BM (left). Data are means ± SD; *, P ≤ 0.05; **, P ≤ 0.01.