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. 2021 May 25;218(7):e20210223. doi: 10.1084/jem.20210223

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© 2021 Ho et al.

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Figure 9. — Known longevity-promoting interventions also fail to rejuvenate old HSCs. (A–E) Effect of exercise on HSCs isolated from young and old sedentary (Sd) or runner (Ru) mice with (A) experimental setup; (B) neurogenesis quantification in the DG of old sedentary or runner mice; and (C) frequency, (D) CD150 levels, and (E) regenerative capacity following transplantation into lethally irradiated recipients (500 HSCs/recipient) for the indicated HSC populations. (F–L) Effects of lifelong calorie restriction on HSCs isolated from old mice fed ad libitum (Al) or calorie restricted (Cr) compared with young controls with (F) experimental setup; (G) weights of the animals; (H) frequency, (I) CD150 levels, (J) regenerative capacity following transplantation into lethally irradiated recipients (500 HSCs/recipient), and (K) MMP for the indicated HSC populations; and (L) frequency and colony-forming activity for the indicated endosteal BM niche populations. MFI, mean fluorescence intensity. Data are means ± SD; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.