Table 1. Drug-Gene Interactions and Pharmacogenomic Variants Identified by Targeted Genotyping.
| Drug | Indication | Gene | SNV testing panel |
|---|---|---|---|
| Amoxapine, aripiprazole, atomoxetine, brexipiprazole, desipramine, fluvoxamine, haloperidol, nortriptyline, paroxetine, quinidine/dextrometorphan, perphenazine, pimozidine, protriptyline, tetrabenazine, thioridazine, valbenazine, venlafaxine, vortioxetine, and zuclopenthixol | Psychiatric disorders | CYP2D6 | rs16947, rs1135840, rs35742686, rs3892097, rs5030655, rs5030867, rs5030865, rs5030656, rs1065852, rs201377835, rs5030864, rs5030862, rs5030865, rs72549357, rs28371706, 4133dupGTGCCCACT, rs72549353, rs72549354, rs59421388, rs28371735, rs28371725, CNV |
| Codeine, hydrocodone, oxycodone, and tramadol | Pain | ||
| Ondansetron, metoclopramide, and tropisetron | Gastrointestinal disorders | ||
| Flecainide and propafenone | Antiarrhythmics | ||
| Metoprolol | β blocker | ||
| Tolteridone | Bladder disorders | ||
| Eliglustat | Gaucher disease | ||
| Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine | Psychiatric disorders | CYP2D6 and CYP2C19 | rs4244285, rs498689, rs28399504, rs56337013, rs72552267, rs72558186, rs41291556, rs12248560 |
| Clopidogrel | Antiplatelet agent | CYP2C19 | rs4244285, rs498689, rs28399504, rs56337013, rs72552267, rs72558186, rs41291556, rs12248560 |
| Citalopram, clobazam, escitalopram, and sertraline | Psychiatric disorders | ||
| Dexlansoprazole, lansoprazole, omeprazole, and pantoprazole | Gastrointestinal disorders | ||
| Voriconazole | Infectious diseases | ||
| Carisoprodol | Pain | ||
| Warfarin | Anticoagulant | VKORC1 and CYP2C9 | rs9923231 (1639 G>A), rs1799853, rs1057910, rs56165452, rs28371686, rs9332131, rs7900194, rs28371685, rs9332239, rs72558187, rs72558190 |
| Phenytoin, siponimod, and lesinurad | Neurologic disorders | CYP2C9 | rs1799853, rs1057910, rs56165452, rs28371686, rs9332131, rs7900194, rs28371685, rs9332239, rs72558187, rs72558190 |
| Celecoxib, flurbiprofen, ibuprofen, and meloxicam piroxicam | Pain | ||
| Dronabinol | Antiemetic | ||
| Azathioprine, mercaptopurine, and thioguanine | Autoimmune disorders and cancer | TPMT | rs1142345, rs1800460, rs1800462, rs1800584 |
| Tacrolimus | Organ transplantation | CYP3A5 | rs28365083, rs776746, rs10264272, rs41303343 |
Abbreviations: CNV, copy number variant; SNV, single nucleotide variant.