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. 2021 May 14;26(10):2921. doi: 10.3390/molecules26102921

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of the participation of opioid receptors (with naltrexone), 5HT1,5 receptors (with methiothepin), and cyclic GMP (with ODQ) in the antinociceptive activity of polyalthic acid (320 mg/kg) in rats submitted to 1% formalin test. Naltrexone, methiothepin and ODQ were intraperitoneally injected into the animals 10 min before administering polyalthic acid. The effect is shown of the pretreatment with (A) naltrexone (1 mg/kg, i.p.), (B) methiothepin (0.1 mg/kg, i.p.) and (C) ODQ (2 mg/kg, i.p.). Data are expressed as the mean number of flinches ± SEM (n = 6). * p < 0.0001 vs. the vehicle group; ^# p < 0.001 vs. polyalthic acid in the absence of pretreatment; significance was determined by one-way ANOVA followed by the Student-Newman-Keuls test.

Evaluation of the participation of opioid receptors (with naltrexone), 5HT1,5 receptors (with methiothepin), and cyclic GMP (with ODQ) in the antinociceptive activity of polyalthic acid (320 mg/kg) in rats submitted to 1% formalin test. Naltrexone, methiothepin and ODQ were intraperitoneally injected into the animals 10 min before administering polyalthic acid. The effect is shown of the pretreatment with (A) naltrexone (1 mg/kg, i.p.), (B) methiothepin (0.1 mg/kg, i.p.) and (C) ODQ (2 mg/kg, i.p.). Data are expressed as the mean number of flinches ± SEM (n = 6). * p < 0.0001 vs. the vehicle group; ^# p < 0.001 vs. polyalthic acid in the absence of pretreatment; significance was determined by one-way ANOVA followed by the Student-Newman-Keuls test.